Scan run #31

Started 11-oct-2026 22:00 · finished 11-oct-2026 22:19 · triggered by cron

Items fetched	Relevant	Stored	New pages
51	11	11	4

New pages this run

The "4" New pages column above counts new wiki pages created across every area (the column name new_mechanisms is a v1 holdover — it covers mechanisms + treatments + subtypes + transplant-timing + symptoms + lifestyle).

Area	Page	Mentions to date
Mechanisms & Pathways	Erythrocyte rigidity and clot pathology in JAK2-MPN	1
Disease Subtypes	Myeloid/lymphoid neoplasms with PCM1::JAK2 (MLN-JAK2)	1
Stem Cell Transplant Decisions	CALR-mutated MPN outcome heterogeneity from HMR co-mutations	1
Treatments	AG-236	1

Dynamic queries this run

SPEC-V2.4 — the expander proposes new searches for pages that have crossed their mention threshold. They run on subsequent scans alongside the static spec queries.

Metric	Count
New queries proposed	3
Active queries that fired	1
Items pulled in via dynamic queries	3
Queries auto-demoted this run	0

Proposed this run

Page	Source	Query	Rationale	Status
Bone marrow fibrosis	pubmed	`("SLAMF7"[Title/Abstract] OR elotuzumab[Title/Abstract] OR "anti-SLAMF7"[Title/Abstract] OR CD319[Title/Abstract]) AND (fibrocyte[Title/Abstract] OR fibrocytes[Title/Abstract] OR "bone marrow fibrosis"[Title/Abstract] OR "marrow fibrosis"[Title/Abstract] OR myelofibrosis[Title/Abstract] OR "collagen-producing"[Title/Abstract] OR "collagen deposition"[Title/Abstract])`	Catches SLAMF7/elotuzumab immunotherapy evidence on fibrocytes and marrow fibrosis in MPN or adjacent settings, which no existing query covers.	active
Inflammatory cytokine signaling	pubmed	`"ruxolitinib"[Title/Abstract] AND (pruritus[Title/Abstract] OR itch[Title/Abstract] OR itching[Title/Abstract] OR aquagenic[Title/Abstract]) AND (myelofibrosis[Title/Abstract] OR "polycythemia vera"[Title/Abstract] OR myeloproliferative[Title/Abstract] OR MPN[Title/Abstract] OR "IL-6"[Title/Abstract] OR TNF[Title/Abstract] OR cytokine[Title/Abstract] OR JAK[Title/Abstract])`	Pairs ruxolitinib specifically with pruritus/itch endpoints and cytokine/JAK context to catch confirming or disconfirming symptom-response evidence not covered by broader ruxolitinib, night-sweat, or IL-6/TNF queries.	active
JAK-STAT signaling	pubmed	`("ropeginterferon"[Title/Abstract] OR Besremi[Title/Abstract] OR "ropeginterferon alfa-2b"[Title/Abstract]) AND (microvascular[Title/Abstract] OR erythromelalgia[Title/Abstract] OR "symptom burden"[Title/Abstract] OR "MPN-SAF"[Title/Abstract] OR pruritus[Title/Abstract] OR headache[Title/Abstract]) AND ("allele burden"[Title/Abstract] OR "JAK-STAT"[Title/Abstract] OR "molecular response"[Title/Abstract] OR "variant allele frequency"[Title/Abstract] OR pSTAT[Title/Abstract])`	Links ropeginterferon/Besremi specifically to microvascular or symptom outcomes plus allele-burden/JAK-STAT readouts, catching confirming or disconfirming evidence for the hypothesis without duplicating the broader ropeginterferon, peg-IFN, or CHIP-constrained queries.	active