Scan run #30

Started 04-oct-2026 22:00 · finished 04-oct-2026 22:21 · triggered by cron

Items fetched	Relevant	Stored	New pages
72	17	16	12

New pages this run

The "12" New pages column above counts new wiki pages created across every area (the column name new_mechanisms is a v1 holdover — it covers mechanisms + treatments + subtypes + transplant-timing + symptoms + lifestyle).

Area	Page	Mentions to date
Lifestyle & Environmental Factors	Ascorbic Acid (Vitamin C) Supplementation	1
Mechanisms & Pathways	Bone marrow macrophage microenvironment in CMML	1
Mechanisms & Pathways	PIM1 kinase signaling in MPN	1
Treatments	Ascorbic acid plus combination chemotherapy (CMML/CCUS)	1
Treatments	DMR-001 (mutant CALR-targeted antibody)	1
Treatments	Lustracept (MF-associated anemia)	1
Treatments	Mutant CALR BiTEs and antibody-drug conjugates	1
Treatments	Mutant CALR CAR-T cells	1
Treatments	Mutant CALR peptide vaccine	2
Treatments	Mutant CALR-specific monoclonal antibodies	1
Treatments	Navtemadlin (MDM2 inhibitor)	1
Treatments	PIM kinase inhibitors (MPN)	1

Dynamic queries this run

SPEC-V2.4 — the expander proposes new searches for pages that have crossed their mention threshold. They run on subsequent scans alongside the static spec queries.

Metric	Count
New queries proposed	4
Active queries that fired	2
Items pulled in via dynamic queries	6
Queries auto-demoted this run	0

Proposed this run

Page	Source	Query	Rationale	Status
Clonal hematopoiesis	pubmed	`"INCA033989"[Title/Abstract] AND ("clonal hematopoiesis"[Title/Abstract] OR CHIP[Title/Abstract] OR "clonal haematopoiesis"[Title/Abstract] OR "allele burden"[Title/Abstract] OR "variant allele frequency"[Title/Abstract] OR "mutant clone"[Title/Abstract] OR "clonal depletion"[Title/Abstract] OR "selective depletion"[Title/Abstract] OR "clone reduction"[Title/Abstract])`	Existing INCA033989 queries cover disease labels and splenomegaly/signaling but miss clonal-dynamics endpoints (CHIP, allele burden, mutant-clone depletion) that would confirm or refute the selective mutant-CALR CH mechanism.	active
Bone marrow fibrosis	pubmed	`("elritercept"[Title/Abstract] OR "KER-050"[Title/Abstract] OR "KER050"[Title/Abstract]) AND (myelofibrosis[Title/Abstract] OR "bone marrow fibrosis"[Title/Abstract] OR myeloproliferative[Title/Abstract] OR MDS[Title/Abstract] OR myelodysplastic[Title/Abstract] OR "TGF-beta"[Title/Abstract] OR "TGF-β"[Title/Abstract] OR activin[Title/Abstract] OR "ligand trap"[Title/Abstract] OR ActRII[Title/Abstract])`	No existing query covers elritercept/KER-050; this catches confirming or disproving evidence on its TGF-β superfamily ligand-trap effects on marrow fibrosis in MF and adjacent MDS/anemia contexts.	active
Inflammatory cytokine signaling	pubmed	`("BET inhibitor"[Title/Abstract] OR "BET bromodomain"[Title/Abstract] OR bromodomain[Title/Abstract]) AND ("NF-κB"[Title/Abstract] OR "NF-kappaB"[Title/Abstract] OR "NF-kB"[Title/Abstract]) AND ("IL-6"[Title/Abstract] OR "interleukin-6"[Title/Abstract] OR "TNF"[Title/Abstract] OR "tumor necrosis factor"[Title/Abstract] OR "night sweats"[Title/Abstract] OR cytokine[Title/Abstract])`	Catches BET–NF-κB–IL-6/TNF/night-sweat mechanism papers in any population, which existing pelabresib-only, MPN-restricted cytokine/NF-κB, and BET+MPN queries do not cover.	active
JAK-STAT signaling	pubmed	`"ruxolitinib"[Title/Abstract] AND ("night sweats"[Title/Abstract] OR "night sweat"[Title/Abstract] OR diaphoresis[Title/Abstract] OR "constitutional symptoms"[Title/Abstract] OR "symptom response"[Title/Abstract]) AND (myelofibrosis[Title/Abstract] OR "polycythemia vera"[Title/Abstract] OR myeloproliferative[Title/Abstract] OR MPN[Title/Abstract] OR cytokine[Title/Abstract])`	Targets ruxolitinib effects on night sweats/constitutional symptoms (confirming or disproving the hypothesis) which no existing ruxolitinib, cytokine, or JAK-STAT query isolates.	active