| Clonal hematopoiesis |
pubmed |
("bomedemstat"[Title/Abstract] OR "IMG-7289"[Title/Abstract] OR "MK-3543"[Title/Abstract] OR "LSD1 inhibitor"[Title/Abstract] OR "LSD1 inhibition"[Title/Abstract]) AND ("clonal hematopoiesis"[Title/Abstract] OR CHIP[Title/Abstract] OR splenomegaly[Title/Abstract] OR "spleen volume"[Title/Abstract] OR "allele burden"[Title/Abstract] OR "clonal fitness"[Title/Abstract] OR "mutant clone"[Title/Abstract]) |
Targets bomedemstat/LSD1 inhibition linked to splenomegaly and clonal fitness endpoints, including non-MPN CHIP/myeloid contexts the existing MPN-only bomedemstat query misses. |
active |
| Inflammatory cytokine signaling |
pubmed |
("NK cell"[Title/Abstract] OR "NK cells"[Title/Abstract] OR "natural killer"[Title/Abstract]) AND (interferon[Title/Abstract] OR ropeginterferon[Title/Abstract] OR "type-I interferon"[Title/Abstract] OR "type I interferon"[Title/Abstract]) AND ("polycythemia vera"[Title/Abstract] OR myelofibrosis[Title/Abstract] OR myeloproliferative[Title/Abstract] OR JAK2[Title/Abstract] OR fatigue[Title/Abstract]) |
Targets the IFN–NK clone-clearance mechanism and fatigue link for ropeginterferon that existing ropeginterferon, cytokine, and QoL queries do not specifically cover. |
active |
| JAK-STAT signaling |
pubmed |
"INCA033989"[Title/Abstract] AND ("splenomegaly"[Title/Abstract] OR "spleen volume"[Title/Abstract] OR "spleen size"[Title/Abstract] OR "spleen response"[Title/Abstract] OR "JAK-STAT"[Title/Abstract] OR pSTAT5[Title/Abstract] OR MPL[Title/Abstract]) |
Targets INCA033989 with splenomegaly and CALR–MPL–JAK-STAT mechanism/readout terms rather than disease labels, catching confirming or disconfirming spleen and pathway evidence in adjacent models the existing drug+MPN query can miss. |
active |
| Diet and Nutrition |
pubmed |
("Mediterranean diet"[Title/Abstract] OR "anti-inflammatory diet"[Title/Abstract] OR "dietary pattern"[Title/Abstract] OR "nutritional intervention"[Title/Abstract] OR "dietary iron"[Title/Abstract] OR "iron intake"[Title/Abstract] OR nutrition[Title/Abstract]) AND ("myeloproliferative"[Title/Abstract] OR "polycythemia vera"[Title/Abstract] OR myelofibrosis[Title/Abstract] OR "essential thrombocythemia"[Title/Abstract] OR MPN[Title/Abstract]) |
Catches diet-pattern, Mediterranean/anti-inflammatory nutrition, and dietary iron literature for MPNs not covered by the existing supplement/antioxidant or hepcidin-pathway queries. |
active |
| Azacitidine (5-AZA) |
pubmed |
("azacitidine"[Title/Abstract] OR "5-azacitidine"[Title/Abstract] OR "5-AZA"[Title/Abstract] OR Vidaza[Title/Abstract]) AND (myeloproliferative[Title/Abstract] OR myelofibrosis[Title/Abstract] OR "polycythemia vera"[Title/Abstract] OR "essential thrombocythemia"[Title/Abstract] OR CMML[Title/Abstract] OR "chronic myelomonocytic"[Title/Abstract] OR "MDS/MPN"[Title/Abstract] OR JMML[Title/Abstract]) |
Targets azacitidine/5-AZA/Vidaza specifically (not the broader epigenetic/decitabine bundle already running) and adds CMML, JMML, and MDS/MPN overlap terms that match tagged findings and are missing from the existing azacitidine-containing query. |
active |
| Fludarabine + Busulfan conditioning regimen |
pubmed |
("fludarabine"[Title/Abstract] AND "busulfan"[Title/Abstract]) AND (conditioning[Title/Abstract] OR "reduced-intensity"[Title/Abstract] OR RIC[Title/Abstract] OR "stem cell transplantation"[Title/Abstract]) AND (myelofibrosis[Title/Abstract] OR "myeloproliferative"[Title/Abstract] OR MPN[Title/Abstract] OR "polycythemia vera"[Title/Abstract]) |
Targets fludarabine/busulfan conditioning specifically for MPN allotransplant, which no existing static or dynamic query covers. |
active |
| INCA033989 (novel investigational agent for MPN) |
pubmed |
INCA033989[Title/Abstract] AND (myeloproliferative OR myelofibrosis OR "essential thrombocythemia" OR MPN OR CALR) |
Targets the specific investigational agent INCA033989 by name, which no existing static or dynamic query covers, while broader mutant-CALR queries miss drug-specific papers. |
active |
| Inflammatory cytokine signaling |
pubmed |
("NLRP3"[Title/Abstract] OR inflammasome[Title/Abstract] OR "interleukin-1"[Title/Abstract] OR "IL-1beta"[Title/Abstract] OR "IL-1β"[Title/Abstract] OR "NF-kappaB"[Title/Abstract] OR "NF-κB"[Title/Abstract]) AND ("myeloproliferative"[Title/Abstract] OR myelofibrosis[Title/Abstract] OR "polycythemia vera"[Title/Abstract] OR "essential thrombocythemia"[Title/Abstract]) |
Captures upstream inflammasome/IL-1/NF-κB inflammatory signaling in MPN that existing IL-6/IL-8/TNF and drug-tied canakinumab/anakinra queries miss. |
active |
| CALR mutations |
pubmed |
("mutant calreticulin"[Title/Abstract] OR "mutant CALR"[Title/Abstract] OR "CALR-directed"[Title/Abstract] OR "anti-CALR"[Title/Abstract] OR "CALR neoantigen"[Title/Abstract]) AND (myeloproliferative OR myelofibrosis OR "essential thrombocythemia" OR MPN) |
Pulls mutant-CALR biology and CALR-directed/immunotherapy papers in MPN without requiring exon-9/type-1/type-2/MPL terms already used by the existing CALR dynamic query. |
active |
| JAK-STAT signaling |
pubmed |
("STAT5"[Title/Abstract] OR "STAT3"[Title/Abstract] OR pSTAT5[Title/Abstract] OR "STAT phosphorylation"[Title/Abstract]) AND ("JAK2"[Title/Abstract] OR "Janus kinase"[Title/Abstract]) AND (myeloproliferative[Title/Abstract] OR myelofibrosis[Title/Abstract] OR "polycythemia vera"[Title/Abstract] OR "essential thrombocythemia"[Title/Abstract]) |
Catches STAT3/STAT5-centric JAK2 pathway mechanism papers that omit the exact phrase JAK-STAT already covered by the existing dynamic query. |
active |