| Stress and Psychological Factors |
pubmed |
("psychological stress"[Title/Abstract] OR "anxiety"[Title/Abstract] OR "depression"[Title/Abstract] OR "mindfulness"[Title/Abstract] OR "mind-body"[Title/Abstract] OR "quality of life"[Title/Abstract]) AND ("myeloproliferative"[Title/Abstract] OR "myelofibrosis"[Title/Abstract] OR "polycythemia vera"[Title/Abstract] OR "essential thrombocythemia"[Title/Abstract]) |
Targets psychological/stress/QoL interventions in MPN patients, a dimension not covered by any existing query which focus on cytokines, treatments, mutations, or dietary factors. |
active |
| ASTX727 (oral cedazuridine + decitabine) |
pubmed |
("ASTX727"[Title/Abstract] OR "cedazuridine"[Title/Abstract] OR "oral decitabine"[Title/Abstract]) AND ("myeloproliferative"[Title/Abstract] OR "MPN"[Title/Abstract] OR "myelofibrosis"[Title/Abstract] OR "CMML"[Title/Abstract] OR "MDS/MPN"[Title/Abstract]) AND ("pharmacokinetics"[Title/Abstract] OR "bioavailability"[Title/Abstract] OR "clinical trial"[Title/Abstract] OR "phase"[Title/Abstract] OR "response"[Title/Abstract]) |
Existing dynamic queries for ASTX727 require co-occurrence with venetoclax or iadademstat/LSD1/decitabine; this query captures standalone ASTX727/cedazuridine clinical and pharmacokinetic studies in MPN/CMML contexts not covered by those constraints. |
demoted |
| AJ1-11095 (Type II JAK2 inhibitor) |
pubmed |
"AJ1-11095"[Title/Abstract] OR ("type II JAK2 inhibitor"[Title/Abstract] AND ("myelofibrosis"[Title/Abstract] OR "myeloproliferative"[Title/Abstract])) |
Targets AJ1-11095 specifically and the novel type II JAK2 inhibitor mechanism class, neither of which is covered by any existing query. |
active |
| ASTX727 + Venetoclax combination (CMML / MDS-MPN) |
pubmed |
"venetoclax"[Title/Abstract] AND ("CMML"[Title/Abstract] OR "chronic myelomonocytic leukemia"[Title/Abstract] OR "MDS/MPN"[Title/Abstract]) AND ("BCL-2"[Title/Abstract] OR "BCL2"[Title/Abstract]) AND ("hypomethylating"[Title/Abstract] OR "azacitidine"[Title/Abstract] OR "decitabine"[Title/Abstract]) |
The existing dynamic query covers ASTX727+venetoclax specifically; this query broadens to capture HMA+venetoclax combination rationale and outcomes literature in CMML/MDS-MPN more generally, including BCL-2 biology context not yet covered. |
demoted |
| Inflammatory cytokine signaling |
pubmed |
("inflammatory cytokine"[Title/Abstract] OR "cytokine storm"[Title/Abstract] OR "cytokine profile"[Title/Abstract] OR "proinflammatory"[Title/Abstract]) AND ("constitutional symptoms"[Title/Abstract] OR "fatigue"[Title/Abstract] OR "pruritus"[Title/Abstract] OR "clonal advantage"[Title/Abstract]) AND ("myeloproliferative"[Title/Abstract] OR "myelofibrosis"[Title/Abstract] OR "polycythemia vera"[Title/Abstract] OR "essential thrombocythemia"[Title/Abstract]) |
The existing IL-6/TNF-alpha query covers specific cytokines but misses broader inflammatory cytokine signaling in the context of MPN constitutional symptoms and clonal advantage, which is the core concept of this page. |
demoted |
| DNA hypomethylation and epigenetic reprogramming |
pubmed |
("DNA hypomethylation"[Title/Abstract] OR "epigenetic reprogramming"[Title/Abstract] OR "DNMT3A"[Title/Abstract] OR "TET2"[Title/Abstract] OR "azacitidine"[Title/Abstract] OR "decitabine"[Title/Abstract]) AND ("myeloproliferative"[Title/Abstract] OR "myelofibrosis"[Title/Abstract] OR "polycythemia vera"[Title/Abstract] OR "essential thrombocythemia"[Title/Abstract]) |
Targets DNA methylation machinery and hypomethylating agents specifically in MPN context, which existing queries only touch tangentially via CHIP/TET2/DNMT3A in clonal hematopoiesis or azacitidine in blast-phase combinations. |
active |
| MPL mutations |
pubmed |
"MPL"[Title/Abstract] AND ("W515"[Title/Abstract] OR "S505"[Title/Abstract] OR "Y591"[Title/Abstract] OR "R592"[Title/Abstract] OR "exon 10"[Title/Abstract]) AND ("thrombopoietin receptor"[Title/Abstract] OR "JAK2 activation"[Title/Abstract] OR "signaling"[Title/Abstract]) AND ("essential thrombocythemia" OR "myelofibrosis" OR "myeloproliferative") |
The existing MPL dynamic query covers W515L/K and general MPL mutations, but this query adds rare/novel MPL variants (S505, Y591, R592, exon 10) and links them to downstream signaling mechanisms, capturing variant-characterization and functional studies not retrieved by the current query. |
demoted |