| Diet and Nutrition |
pubmed |
("Mediterranean diet"[Title/Abstract] OR "anti-inflammatory diet"[Title/Abstract] OR "dietary iron"[Title/Abstract] OR "iron intake"[Title/Abstract] OR "nutrition"[Title/Abstract]) AND ("myeloproliferative"[Title/Abstract] OR "polycythemia vera"[Title/Abstract] OR "myelofibrosis"[Title/Abstract] OR "essential thrombocythemia"[Title/Abstract]) |
Existing queries cover supplements/antioxidants but not broader dietary patterns (Mediterranean diet, anti-inflammatory diet) or dietary iron management relevant to PV, which are the core of this page's current understanding. |
demoted |
| Pelabresib (BET bromodomain inhibitor) |
pubmed |
"pelabresib"[Title/Abstract] AND ("ruxolitinib"[Title/Abstract] OR "JAK inhibitor"[Title/Abstract] OR "combination therapy"[Title/Abstract] OR "spleen volume"[Title/Abstract] OR "symptom burden"[Title/Abstract]) AND ("myelofibrosis"[Title/Abstract] OR "myeloproliferative"[Title/Abstract]) |
The existing query 'pelabresib'[Title/Abstract] OR 'CPI-0610'[Title/Abstract] is broad but lacks context filters; this query targets pelabresib specifically in combination/clinical outcome contexts within MF/MPN, capturing combination trial and efficacy papers not guaranteed by the bare name search. |
demoted |
| Phlebotomy-only maintenance in PV |
pubmed |
"phlebotomy"[Title/Abstract] AND ("polycythemia vera"[Title/Abstract] OR "polycythaemia vera"[Title/Abstract]) AND ("low-risk"[Title/Abstract] OR "maintenance"[Title/Abstract] OR "watchful waiting"[Title/Abstract] OR "aspirin alone"[Title/Abstract] OR "without cytoreduction"[Title/Abstract]) |
The existing phlebotomy query focuses on hematocrit/cytoreduction/monotherapy framing; this query targets the phlebotomy-only maintenance concept specifically by adding 'maintenance', 'watchful waiting', and 'without cytoreduction' terms not covered by any existing query. |
demoted |
| INCA033989 (novel investigational agent for MPN) |
pubmed |
"INCA033989"[Title/Abstract] OR ("anti-CALR"[Title/Abstract] AND "monoclonal antibody"[Title/Abstract] AND ("myeloproliferative"[Title/Abstract] OR "essential thrombocythemia"[Title/Abstract] OR "myelofibrosis"[Title/Abstract])) |
The existing dynamic query covers INCA033989 by title/abstract alone; this expands coverage by also capturing anti-CALR monoclonal antibody papers that may describe INCA033989 without naming it, while the existing mutant-CALR immunotherapy query requires 'immunotherapy OR antibody OR vaccine OR targeted therapy OR neoantigen' and misses papers framed around the antibody mechanism specifically. |
demoted |
| Clonal hematopoiesis |
pubmed |
("clonal hematopoiesis"[Title/Abstract] OR "CHIP"[Title/Abstract]) AND ("TET2"[Title/Abstract] OR "DNMT3A"[Title/Abstract] OR "ASXL1"[Title/Abstract]) AND ("myeloproliferative"[Title/Abstract] OR "myelofibrosis"[Title/Abstract] OR "polycythemia vera"[Title/Abstract] OR "essential thrombocythemia"[Title/Abstract]) |
Targets clonal hematopoiesis specifically via co-occurring epigenetic driver mutations (TET2, DNMT3A, ASXL1) in MPN context, which existing queries don't cover — the closest existing query focuses on JAK2/CALR and clonal architecture rather than these CHIP-defining mutations. |
active |
| Thrombosis risk |
pubmed |
("cardiovascular risk score"[Title/Abstract] OR "IPSET-thrombosis"[Title/Abstract] OR "thrombotic risk stratification"[Title/Abstract] OR "venous thromboembolism"[Title/Abstract]) AND ("polycythemia vera"[Title/Abstract] OR "essential thrombocythemia"[Title/Abstract] OR "myeloproliferative"[Title/Abstract]) |
Targets clinical risk stratification tools and venous thromboembolism specifically in MPN, which the existing thrombosis query covers mechanistically (hematocrit, leukocytosis, allele burden) but not from a scoring/stratification angle. |
active |
| JAK-STAT signaling |
pubmed |
"JAK-STAT"[Title/Abstract] AND ("myeloproliferative"[Title/Abstract] OR "myelofibrosis"[Title/Abstract] OR "polycythemia vera"[Title/Abstract] OR "essential thrombocythemia"[Title/Abstract]) AND ("pathway"[Title/Abstract] OR "activation"[Title/Abstract] OR "inhibition"[Title/Abstract] OR "signaling"[Title/Abstract]) |
Existing queries cover JAK2/STAT3/STAT5 individually or JAK2 V617F specifically, but none target the broader 'JAK-STAT' pathway term as a combined concept in MPN contexts, which would capture mechanistic and review articles framing the pathway holistically. |
active |