Scan run #15

Started 22-jun-2026 19:35 · finished 22-jun-2026 19:39 · triggered by user 1

Items fetched	Relevant	Stored	New pages
47	4	4	2

New pages this run

The "2" New pages column above counts new wiki pages created across every area (the column name new_mechanisms is a v1 holdover — it covers mechanisms + treatments + subtypes + transplant-timing + symptoms + lifestyle).

Area	Page	Mentions to date
Treatments	Cytokine-induced memory-like (CIML) NK cells in myeloid malignancies	1
Treatments	Mutant CALR peptide vaccine (MPN immunotherapy)	1

Dynamic queries this run

SPEC-V2.4 — the expander proposes new searches for pages that have crossed their mention threshold. They run on subsequent scans alongside the static spec queries.

Metric	Count
New queries proposed	7
Active queries that fired	2
Items pulled in via dynamic queries	0
Queries auto-demoted this run	3

Proposed this run

Page	Source	Query	Rationale	Status
Diet and Nutrition	pubmed	`("curcumin"[Title/Abstract] OR "N-acetylcysteine"[Title/Abstract] OR "antioxidant"[Title/Abstract] OR "omega-3"[Title/Abstract] OR "dietary supplement"[Title/Abstract]) AND ("myeloproliferative"[Title/Abstract] OR "polycythemia vera"[Title/Abstract] OR "myelofibrosis"[Title/Abstract] OR "essential thrombocythemia"[Title/Abstract])`	The existing diet query covers broad dietary/nutritional terms but misses specific nutraceutical/supplement interventions (curcumin, NAC, antioxidants, omega-3) that are directly reflected in the tagged findings and the page's anti-inflammatory focus.	active
Hydroxyurea	pubmed	`"hydroxyurea"[MeSH Terms] AND ("polycythemia vera"[Title/Abstract] OR "essential thrombocythemia"[Title/Abstract] OR "myeloproliferative"[Title/Abstract]) AND ("disease modification"[Title/Abstract] OR "molecular response"[Title/Abstract] OR "thrombosis prevention"[Title/Abstract] OR "cardiovascular risk"[Title/Abstract] OR "long-term"[Title/Abstract])`	The existing hydroxyurea dynamic query focuses on resistance/intolerance/cytoreduction/hematocrit; this targets hydroxyurea's long-term outcomes, disease modification potential, and cardiovascular/thrombosis prevention role using the MeSH term anchor, covering a distinct clinical dimension.	active
Ropeginterferon alfa-2b (Besremi)	pubmed	`"pegylated interferon"[Title/Abstract] AND ("polycythemia vera"[Title/Abstract] OR "essential thrombocythemia"[Title/Abstract] OR "myeloproliferative"[Title/Abstract]) AND ("allele burden"[Title/Abstract] OR "disease modification"[Title/Abstract] OR "molecular remission"[Title/Abstract] OR "hematologic response"[Title/Abstract])`	The existing 'ropeginterferon' query covers that specific drug name, but this query captures broader pegylated interferon literature (including ropeg studies that may not use the brand/INN name) focused on the disease-modifying outcomes central to this page's concept.	active
Ruxolitinib	pubmed	`"ruxolitinib"[Title/Abstract] AND ("splenomegaly"[Title/Abstract] OR "allele burden"[Title/Abstract] OR "JAK inhibitor"[Title/Abstract] OR "resistance"[Title/Abstract] OR "suboptimal response"[Title/Abstract]) AND (myelofibrosis[Title/Abstract] OR "polycythemia vera"[Title/Abstract])`	The existing ruxolitinib query is broad; this targets mechanistic and clinical outcome dimensions (splenomegaly reduction, allele burden, resistance/suboptimal response) not covered by any current query, aligning with the page's current understanding.	active
Clonal hematopoiesis	pubmed	`("hematopoietic stem cell"[Title/Abstract] OR "stem cell competition"[Title/Abstract] OR "clonal architecture"[Title/Abstract] OR "allele burden"[Title/Abstract]) AND ("JAK2"[Title/Abstract] OR "CALR"[Title/Abstract] OR "myeloproliferative"[Title/Abstract]) AND ("clonal expansion"[Title/Abstract] OR "clonal evolution"[Title/Abstract] OR "variant allele frequency"[Title/Abstract])`	Targets the stem-cell competition and clonal architecture angle of clonal hematopoiesis in MPNs, which the existing 'clonal hematopoiesis' dynamic query doesn't capture at the mechanistic stem-cell level.	active
CALR mutations	pubmed	`("mutant CALR"[Title/Abstract] OR "CALR mutation"[Title/Abstract] OR "calreticulin mutation"[Title/Abstract]) AND ("immunotherapy"[Title/Abstract] OR "antibody"[Title/Abstract] OR "vaccine"[Title/Abstract] OR "targeted therapy"[Title/Abstract] OR "neoantigen"[Title/Abstract]) AND ("myeloproliferative"[Title/Abstract] OR "essential thrombocythemia"[Title/Abstract] OR "myelofibrosis"[Title/Abstract])`	Existing CALR query covers exon 9/type/MPL mechanistic angle; this query targets the immunotherapy and directed-agent therapeutic angle highlighted in recent findings, which no existing query captures.	demoted
JAK-STAT signaling	pubmed	`"JAK2"[Title/Abstract] AND ("STAT3"[Title/Abstract] OR "STAT5"[Title/Abstract]) AND ("signaling pathway"[Title/Abstract] OR "signal transduction"[Title/Abstract] OR "phosphorylation"[Title/Abstract]) AND ("myeloproliferative"[Title/Abstract] OR "myelofibrosis"[Title/Abstract] OR "polycythemia vera"[Title/Abstract] OR "essential thrombocythemia"[Title/Abstract])`	Existing queries cover JAK-STAT broadly and JAK2 V617F structurally (JH2/pseudokinase), but none specifically target the downstream STAT3/STAT5 effector signaling mechanics that are central to this page's focus on constitutive pathway activation in MPN clonal proliferation.	demoted

Demoted this run

Page	Source	Query	Reason
Diet and Nutrition	pubmed	`("diet"[Title/Abstract] OR "nutrition"[Title/Abstract] OR "Mediterranean diet"[Title/Abstract] OR "anti-inflammatory diet"[Title/Abstract] OR "iron intake"[Title/Abstract]) AND ("myeloproliferative" OR "polycythemia vera" OR "myelofibrosis" OR "essential thrombocythemia")`	0 relevant hits over 4 scans (min 1)
Clonal hematopoiesis	pubmed	`"clonal hematopoiesis"[Title/Abstract] AND ("myeloproliferative" OR "polycythemia vera" OR "myelofibrosis" OR "essential thrombocythemia")`	0 relevant hits over 4 scans (min 1)
JAK-STAT signaling	pubmed	`"JAK-STAT"[Title/Abstract] AND ("myeloproliferative" OR "myelofibrosis" OR "polycythemia vera" OR "essential thrombocythemia")`	0 relevant hits over 4 scans (min 1)