| INCB057643 (BET bromodomain inhibitor) |
biorxiv |
INCB057643 BET bromodomain inhibitor myelofibrosis |
Targets INCB057643 specifically as a BET bromodomain inhibitor in myeloproliferative/myelofibrosis context, which no existing query covers. |
manually-archived |
| INCB057643 (BET bromodomain inhibitor) |
pubmed |
"INCB057643"[Title/Abstract] OR ("BET bromodomain inhibitor"[Title/Abstract] AND ("myelofibrosis"[Title/Abstract] OR "myeloproliferative"[Title/Abstract])) |
Targets INCB057643 specifically and BET bromodomain inhibitors in MPN context, which no existing static or dynamic query covers. |
active |
| INCA033989 (novel investigational agent for MPN) |
biorxiv |
INCA033989 calreticulin antibody myeloproliferative neoplasm |
Targets the specific investigational anti-CALR agent INCA033989 by name alongside its mechanism context, which no existing query covers. |
manually-archived |
| INCA033989 (novel investigational agent for MPN) |
pubmed |
"INCA033989"[Title/Abstract] |
Directly targets this specific investigational anti-CALR antibody by its compound name, which no existing query covers. |
demoted |
| DNA hypomethylation and epigenetic reprogramming |
biorxiv |
DNA hypomethylation epigenetic reprogramming myeloproliferative neoplasm decitabine azacitidine |
Targets the mechanistic basis of hypomethylating agent activity in MPNs—specifically DNA hypomethylation and epigenetic reprogramming—which none of the existing queries address. |
manually-archived |
| DNA hypomethylation and epigenetic reprogramming |
pubmed |
("DNA hypomethylation"[Title/Abstract] OR "hypomethylating agent"[Title/Abstract] OR "epigenetic reprogramming"[Title/Abstract]) AND ("myeloproliferative"[Title/Abstract] OR "myelofibrosis"[Title/Abstract] OR "polycythemia vera"[Title/Abstract] OR "essential thrombocythemia"[Title/Abstract]) |
Targets DNA hypomethylation and epigenetic reprogramming mechanisms specifically in MPN contexts, which no existing static or dynamic query covers. |
demoted |
| CALR mutations |
biorxiv |
CALR mutation calreticulin exon9 frameshift MPL thrombopoietin receptor myeloproliferative |
Targets the specific CALR exon 9 frameshift mechanism and MPL receptor activation in ET/PMF, which none of the existing queries cover. |
manually-archived |
| CALR mutations |
pubmed |
"CALR"[Title/Abstract] AND ("exon 9"[Title/Abstract] OR "type 1"[Title/Abstract] OR "type 2"[Title/Abstract] OR "MPL"[Title/Abstract]) AND ("essential thrombocythemia" OR "myelofibrosis" OR "myeloproliferative") |
The existing static query covers 'calreticulin' broadly, but this query specifically targets CALR mutation mechanistic details (exon 9 frameshift, type 1/2, MPL activation) in MPN context, which the current queries miss. |
active |