| Diet and Nutrition |
biorxiv |
diet nutrition inflammation myeloproliferative neoplasm |
Targets dietary and nutritional interventions in MPN patients, covering anti-inflammatory diet, iron management, and supplement studies not captured by any existing signaling- or treatment-focused queries. |
manually-archived |
| Diet and Nutrition |
pubmed |
("diet"[Title/Abstract] OR "nutrition"[Title/Abstract] OR "Mediterranean diet"[Title/Abstract] OR "anti-inflammatory diet"[Title/Abstract] OR "iron intake"[Title/Abstract]) AND ("myeloproliferative" OR "polycythemia vera" OR "myelofibrosis" OR "essential thrombocythemia") |
Targets dietary and nutritional interventions specifically in MPN populations, which none of the existing static or dynamic queries address. |
demoted |
| Ropeginterferon alfa-2b (Besremi) |
biorxiv |
ropeginterferon alfa-2b polycythemia vera JAK2 allele burden |
Targets ropeginterferon/Besremi specifically in PV with allele burden reduction, which none of the existing queries cover. |
manually-archived |
| Ropeginterferon alfa-2b (Besremi) |
pubmed |
"ropeginterferon"[Title/Abstract] AND ("polycythemia vera" OR "myeloproliferative" OR "JAK2") |
Targets ropeginterferon (Besremi) specifically by name, which no existing static or dynamic query covers, capturing clinical trials, efficacy, and allele burden reduction studies for this drug. |
active |
| Ruxolitinib |
biorxiv |
ruxolitinib myelofibrosis JAK inhibitor splenomegaly response |
Targets ruxolitinib-specific clinical and mechanistic preprints on biorxiv, covering splenomegaly reduction and JAK inhibition in myelofibrosis, which is not addressed by the existing JAK2/STAT signaling or clonal hematopoiesis queries. |
manually-archived |
| Ruxolitinib |
pubmed |
"ruxolitinib"[Title/Abstract] AND (myelofibrosis OR "polycythemia vera" OR "myeloproliferative") |
Directly targets ruxolitinib-specific literature in MPN contexts, which no existing static or dynamic query captures despite it being the page's core concept. |
active |
| Clonal hematopoiesis |
biorxiv |
clonal hematopoiesis stem cell expansion myeloproliferative allele burden |
Targets clonal hematopoiesis dynamics (allele burden, stem-cell competition, clonal architecture) in the MPN context, which is distinct from the existing JAK2/STAT signaling query and not yet covered by any biorxiv static queries. |
manually-archived |
| Clonal hematopoiesis |
pubmed |
"clonal hematopoiesis"[Title/Abstract] AND ("myeloproliferative" OR "polycythemia vera" OR "myelofibrosis" OR "essential thrombocythemia") |
Directly targets clonal hematopoiesis in the MPN context, which the existing dynamic query only partially covers via CHIP/JAK2 pairing, capturing allele burden, stem-cell competition, and clonal architecture studies not retrieved by current queries. |
demoted |
| JAK-STAT signaling |
biorxiv |
JAK2 STAT signaling myeloproliferative |
Targets biorxiv preprints on JAK2-STAT pathway mechanisms in MPNs, covering mechanistic studies not yet in peer-reviewed journals and not duplicated by any existing queries. |
manually-archived |
| JAK-STAT signaling |
pubmed |
"JAK-STAT"[Title/Abstract] AND ("myeloproliferative" OR "myelofibrosis" OR "polycythemia vera" OR "essential thrombocythemia") |
Targets the JAK-STAT signaling pathway phrase directly, which is not covered by existing queries that focus on JAK2 V617F mutation or disease MeSH terms alone. |
demoted |