PLK1 (Polo-like kinase 1) signaling in MPN/CMML
Current understanding
To be populated as evidence accumulates.
Evidence log
- 2026-02-23 — Onvansertib for the Treatment of Recurrent or Refractory Chronic Myelomonocytic Leukemia and Myelodysplastic Syndrome/MPN Overlap Neoplasms: Phase I trial evaluating onvansertib (first-in-class PLK1 inhibitor) for safety, dosing, and efficacy in recurrent/refractory CMML and MDS/MPN overlap neoplasms — first clinical interrogation of PLK1 dependence in these subtypes. (novelty: 4)