NK cell immune surveillance in MPN
Current understanding
To be populated as evidence accumulates.
Evidence log
- 2026-09-01 — Type-I interferon-activated NK cells control polycythemia vera in vivo.: Foundational preclinical evidence establishes that NK cells directly sense basal type-I IFN via IFNAR and preferentially kill JAK2V617F-mutant HSPCs in a TNF-α-dependent manner; loss of NK cells or NK-intrinsic IFNAR accelerates PV even without exogenous IFN-α, defining an endogenous NK-based immune surveillance axis in MPN. (novelty: 5)