MF spleen spatial niche compartments (IV/PV/RP)
Current understanding
To be populated as evidence accumulates.
Evidence log
- 2026-08-03 — Spatially resolved transcriptomic profiling of myelofibrosis spleen reveals compartment specific niche programs.: Spatial whole-transcriptome profiling of MF spleen resolves three compartment-specific niche programs — intravascular endothelial/vascular-stress, perivascular fibro-remodeling with CXCL12 retention cues, and red-pulp EMH marked by S100A8/A9 alarmins — reframing splenomegaly as a structured division of labor across microenvironmental compartments rather than diffuse extramedullary hematopoiesis. (novelty: 4)