Bone marrow mast-cell infiltration and pruritus in MPN
Current understanding
To be populated as evidence accumulates.
Evidence log
- 2026-06-26 — Increased Mast Cell Numbers in Bone Marrow of Patients with Myeloproliferative Neoplasms and Pruritus.: Observational study of untreated MPN patients found significantly higher absolute and relative bone-marrow mast-cell counts in those with clinically significant pruritus versus those without, providing quantitative clinical evidence linking mast-cell burden to MPN-associated pruritus without establishing causality. (novelty: 3)