Inducible caspase-9 (iCasp9) suicide gene T-cell elimination mechanism
Current understanding
To be populated as evidence accumulates.
Evidence log
- 2026-07-01 — CASPALLO: Allodepleted T Cells Transduced With Inducible Caspase 9 Suicide Gene: CASPALLO phase I trial applies iCasp9-transduced allodepleted donor T cells post-haploidentical HSCT, testing whether AP1903-triggered apoptosis can rescue GvHD while permitting higher T-cell doses to accelerate immune reconstitution. (novelty: 4)