Glutamate–mGluR5–fumarate metabolic rewiring of MSCs
Current understanding
To be populated as evidence accumulates.
Evidence log
- 2026-07-09 — Glutamate accumulation in myelofibrosis microenvironment rewires mesenchymal stromal cells metabolic and epigenetic profiles.: Preclinical study identifies glutamate accumulation in the MF microenvironment as the upstream trigger engaging mGluR5 on MSCs, driving α-KGDH upregulation and fumarate hydratase downregulation, fumarate accumulation, epigenetic remodeling, senescence, and fibrosis — with mGluR5 inhibition attenuating the phenotype. (novelty: 5)