DNMT3A mutations
Current understanding
To be populated as evidence accumulates.
Evidence log
- 2026-07-23 — DNMT3A and TET2 Mutations are Associated With Both Venous Thrombosis and Major Bleeding in Patients With Polycythemia Vera and Essential Thrombocythemia.: Observational MPN cohort identifies DNMT3A mutations as significantly associated with venous thrombosis and major bleeding in PV and ET but not MF — an early clinical signal that DNMT3A loss modifies hemostatic risk in chronic-phase MPN. (novelty: 3)