Phenotypic and Functional Characterization of Bone Marrow Macrophages in Chronic Myelomonocytic Leukemia
Key claim: The MAC-AGE study will phenotypically, transcriptionally, and functionally compare bone marrow macrophages in CMML with age-matched controls to define CMML-associated macrophage alterations and candidate therapeutic targets in the marrow immune microenvironment.
Abstract
MAC-AGE is a single-center study designed to characterize bone marrow macrophages in patients with chronic myelomonocytic leukemia (CMML) and to compare them with macrophages from age-matched controls undergoing elective total hip arthroplasty. Phenotypic, transcriptional and functional analyses will be performed using spectral/multiparametric flow cytometry, single-cell RNA sequencing and ex vivo functional assays. The study aims to identify CMML-associated macrophage alterations and potential therapeutic targets within the bone marrow immune microenvironment.
Why this matters
The MAC-AGE study will phenotypically, transcriptionally, and functionally compare bone marrow macrophages in CMML with age-matched controls to define CMML-associated macrophage alterations and candidate therapeutic targets in the marrow immune microenvironment.