Myeloproliferative Neoplasms: an In-depth Case-control Study
Key claim: An exploratory UK case-control study of 100 classic MPN patients and 200 controls is proposed to pilot recruitment, response rates, and a telephone questionnaire ahead of a larger multi-centre aetiology study of medical, environmental, and occupational risk factors.
Abstract
There is a paucity of data on the aetiology of myeloproliferative neoplasms (MPNs). The investigators conducted a systematic review of the literature which identified several cohort and case-control studies that have investigated a wide range of potential medical, environmental and occupational risk factors. However, these studies have been limited by a wide variation in case definition and small sample sizes limiting the potential to detect modest risk differences between cases and controls. The research group propose an exploratory case-control study of 100 patients with classic MPNs and 200 controls to determine the optimal methods for roll out of this study to a multi-centred UK-based case-control study that will investigate the aetiology of MPN subtypes. The objectives of the study are to evaluate recruitment procedures, response rates and the development of a telephone administered questionnaire. The findings of this exploratory study will form the basis of a protocol for a large United Kingdom (UK)-wide case-control study of MPNs.
Why this matters
An exploratory UK case-control study of 100 classic MPN patients and 200 controls is proposed to pilot recruitment, response rates, and a telephone questionnaire ahead of a larger multi-centre aetiology study of medical, environmental, and occupational risk factors.