MPN Watch

Dossier pubmed review 03-aug-2026

Emerging agents and regimens for myeloproliferative neoplasms: updates from ASH 2025 Annual Meeting

Key claim: ASH 2025 updates highlight emerging MPN agents and regimens intended to address infrequent molecular remissions and treatment-limiting cytopenias of current therapies.

Abstract

Expert commentary review discussing emerging agents and regimens for MPN presented at ASH 2025, addressing limitations of current therapies including infrequent molecular remissions and treatment-limiting cytopenias.

Why this matters

ASH 2025 updates highlight emerging MPN agents and regimens intended to address infrequent molecular remissions and treatment-limiting cytopenias of current therapies.

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Briefing card

Emerging agents and regimens for myeloproliferative neoplasms: updates from ASH 2025 Annual Meeting.
Stage: review · pubmed · 03-aug-2026

ASH 2025 updates highlight clone-directed INCA033989, phlebotomy-sparing rusfertide, and epigenetic pelabresib combinations as strategies to overcome limited molecular remissions, treatment-related anemia, and phlebotomy dependence in current MPN care.

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External: doi:10.1186/s40164-026-00813-0

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