Association between JAK2 Mutations and Thoracic Aortic Aneurysms in Myeloproliferative Neoplasms
Key claim: A scoping review identifies an association between JAK2 mutations in myeloproliferative neoplasms and the development of thoracic aortic aneurysms.
Abstract
A scoping review examining MEDLINE, Embase, Web of Science, and prominent hematology and cardiology conference abstracts from inception to August 2025 reviewed abstracts from ASH, EHA, and ACC annual meetings to capture unpublished or recent data on JAK2 mutations and aortic aneurysms in MPNs.
Why this matters
Symptom management in MPNs has historically focused on microvascular phenomena and venous thrombosis, but this scoping review raises the possibility that JAK2 mutation also predisposes to large-vessel aortic wall disease. If validated, it would expand the vascular surveillance footprint for JAK2-positive patients and add a new symptom/complication domain — thoracic aortic aneurysm — to MPN longitudinal care.