UBP310/UBP296 (mGluR5 inhibitors)
Current understanding
To be populated as evidence accumulates.
Evidence log
- 2026-07-09 — Glutamate accumulation in myelofibrosis microenvironment rewires mesenchymal stromal cells metabolic and epigenetic profiles.: Preclinical study identified glutamate accumulation in the MF microenvironment as driving mesenchymal stromal cell reprogramming via mGluR5-mediated fumarate accumulation, epigenetic remodeling, senescence, and fibrosis; mGluR5 inhibition with UBP310/UBP296 attenuated MSC senescence and collagen deposition in vitro and in vivo. (novelty: 5)
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Contributing findings
Glutamate accumulation in myelofibrosis microenvironment rewires mesenchymal stromal cells metabolic and epigenetic profiles.
09-jul-2026
novelty 5
per-area 5
introduces