Low-dose splenic irradiation (pretransplant MF)
Current understanding
To be populated as evidence accumulates.
Evidence log
- 2026-08-23 — Sequential High-Dose Ruxolitinib and Low-Dose Splenic Irradiation for Pretransplant Management of Splenomegaly Before Allogeneic Hematopoietic Cell Transplantation With Fludarabine/Busulfan-Based Conditioning in Myelofibrosis.: Retrospective series (observational): LDSI applied after high-dose ruxolitinib further reduced median spleen length (172→137 mm) before Flu/Bu allo-HCT, supporting sequential local radiotherapy as a spleen-debulking step when JAK-inhibitor response plateaus. (novelty: 3)
Open questions
Related
Contributing findings
Sequential High-Dose Ruxolitinib and Low-Dose Splenic Irradiation for Pretransplant Management of Splenomegaly Before Allogeneic Hematopoietic Cell Transplantation With Fludarabine/Busulfan-Based Conditioning in Myelofibrosis.
23-aug-2026
novelty 3
per-area 3
introduces