FL118 (DDX5 protein degrader)
Current understanding
To be populated as evidence accumulates.
Evidence log
- 2026-07-01 — DDX5: a versatile RNA helicase in cancer and cell fate determination-linking c-Myc and JAK2 V617F signalling to emerging therapeutics.: Review (2024) synthesizes mechanistic rationale for FL118 as a DDX5 protein degrader in JAK2 V617F-driven MPN, describing DDX5 as a helicase-independent scaffolding co-activator required for JAK2 V617F transformation and forming a positive-feedback loop with c-Myc; FL118-mediated DDX5 degradation is proposed as a novel therapeutic strategy (preclinical/mechanistic, no clinical efficacy or safety data yet). (novelty: 4)
Open questions
Related
Contributing findings
DDX5: a versatile RNA helicase in cancer and cell fate determination-linking c-Myc and JAK2 V617F signalling to emerging therapeutics.
01-jul-2026
novelty 4
per-area 4
introduces