Splenic artery aneurysm (MF-associated)

Current understanding

Splenic artery aneurysm (SAA) is a rare vascular complication that may arise in myelofibrosis patients with marked splenomegaly, likely driven by altered splanchnic hemodynamics and increased splenic arterial flow. Management options include spleen-preserving endovascular coil embolization; JAK inhibitor–mediated splenomegaly reduction has been described as a bridging strategy to optimize hemodynamic conditions before intervention. Evidence base is limited to case reports.

Evidence log

• 2025-11-20 — Splenic Artery Aneurysm Associated with Myelofibrosis Managed by Coil Embolization.: cross-connection with splenomegaly: MF-associated splenomegaly can predispose to splenic artery aneurysm via altered splanchnic hemodynamics; ruxolitinib-mediated spleen reduction may facilitate safer endovascular treatment. (novelty: 3)

Open questions

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