Atypical EMH mass-related symptoms (dyspnea, ascites, pain) in MF

Current understanding

To be populated as evidence accumulates.

2026-08-03 — Spatially resolved transcriptomic profiling of myelofibrosis spleen reveals compartment specific niche programs.: Spatial transcriptomics of MF spleen localizes an S100A8/A9 alarmin-high red-pulp EMH program distinct from perivascular fibro-remodeling and intravascular vascular-stress niches, providing a molecular framework that may extend to characterizing extrasplenic EMH mass biology and treatment vulnerabilities. (novelty: 4)
2026-06-30 — A systematic review of 47 published cases of extramedullary hematopoiesis in myelofibrosis: clinical patterns, treatment responses, and prognostic implications.: Systematic review of 47 published atypical EMH cases in myelofibrosis characterized anatomic patterns (thoracic/paraspinal/serosal predominance), symptomatic presentation in ~75% (dyspnea 28%, abdominal pain 21%), frequent response to ruxolitinib and locoregional radiotherapy, and high short-term mortality — supporting surveillance and early transplant referral when atypical EMH is identified. (novelty: 3)