MDM2–p53 axis in MPN
Current understanding
To be populated as evidence accumulates.
Evidence log
- 2026-09-01 — Genomic Evolution of Myeloproliferative Neoplasms and Therapy-Associated Mutagenesis.: cross-connection with mpn-clonal-evolution-trajectories: TP53 biallelic loss defines one of the distinct genomically-encoded evolutionary trajectories to MPN transformation, linking the MDM2–p53 axis to a specific progression route detectable years ahead. (novelty: 4)
Open questions
Related
Contributing findings
Closing the disease modification gap: Emerging therapies in myelofibrosis beyond JAK inhibition.
30-jul-2026
novelty 2
per-area 2
mentions