Lysozyme-associated nephropathy mechanism

Current understanding

To be populated as evidence accumulates.

2026-04-27 — JAK Inhibitor-Induced Improvement of IgA Nephropathy in a Patient With Polycythemia Vera: A Case Report.: cross-connection with mpn-iga-nephropathy-il6-il11-mesangial-axis: Both describe distinct MPN-driven renal injury mechanisms — glomerular/mesangial (IL-6/IL-11, IgA immune complexes) versus proximal tubular (lysozyme overload) — jointly framing the kidney as a shared end-organ target of MPN clonal and inflammatory output. (novelty: 4)
2026-06-16 — Lysozyme-Associated Nephropathy in Myeloid Neoplasms: A Clinicopathological and Mass Spectrometric Study of Two Cases.: First mass spectrometry-based proteomic analysis of LyN proximal tubules in two myeloid neoplasm cases (PMF with progressive monocytosis and CMML) reveals lysosomal system upregulation, lipid metabolism disruption, and cellular stress responses as core mechanisms of chronic lysozyme overload-mediated tubular injury. (novelty: 4)