Fibrocytes as collagen-producing drivers of BM fibrosis in MPN

Current understanding

To be populated as evidence accumulates.

2026-09-01 — Fibrocytes drive JAK2V617F-mutated myelofibrosis: pitavastatin reverses marrow fibrosis and anemia.: Preclinical JAK2V617F MF study establishes monocyte-derived fibrocytes as the dominant collagen-producing population in fibrotic marrow and shows pitavastatin depletes fibrocytes, lowers TGF-β1, and reverses marrow fibrosis and anemia in vivo, nominating fibrocyte inhibition as a first-in-class antifibrotic mechanism. (novelty: 4)