DDX5 RNA helicase scaffolding co-activator in JAK2/MYC signaling

Current understanding

DDX5 is proposed to function as a helicase-independent scaffolding co-activator that is required for JAK2 V617F-driven MPN transformation, and to engage in a positive feedback loop with c-Myc that amplifies proliferative transcriptional output. The small-molecule FL118 is described as a DDX5 degrader with potential therapeutic activity in this axis. Evidence to date is at the review/preclinical synthesis level, so mechanistic and clinical claims remain to be validated in MPN-specific experimental and trial settings.

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